How to evaluate supplement claims
Updated 3 November 2026 · Root & Evidence editorial content · No independent clinical review claimed
On this page Jump to a section ↓
Turn the promise into a question
Which outcome, in which people, using what preparation and dose? “Supports wellness” is not a defined clinical endpoint.
Follow the link to people
Human randomized trials are more directly relevant to treatment effects than cell or animal findings. A plausible mechanism is a reason to study something, not proof that it helps.
Read beyond the headline
Check the comparator, sample size, duration, primary outcome, absolute effect, confidence interval, dropouts, harms, and funding. A nonsignificant result is not proof of equivalence; a significant result may still be small.
Look for the whole picture
One favorable study can coexist with negative trials. Compare methods and populations before explaining conflict. Testimonials, ratings, and shopping popularity do not replace clinical evidence.